We studied the clinical applicability of intraosseous route as a rapidly, easily obtainable venous access route in shock resuscitation using rabbit hemorrhagic shock model. The experiment was conducted after induction of shock by withdrawing
one-third
of blood volume. In the lst experiment. there times of shed blood was replaced with saline solution in intraosseous and in travenous group but no fluid was given to control group. The mean arterial pressure and hematocrit were observed throughout
the
experiment. In the 2nd experiment, the flow rate between gravity and 150 mmHg-pressurized intraosseous infusion was compared.
The results were as follows . In the lst experiment, all three groups showed a drop in MAP to at least 40% of the baseline value after induction of hemorrhage. At 5min after beginning of fluid administration, the MAP was elevated to 105% and 100%
of
baseline in the intraosseous and intravenous group, respectively. After fluid infusion was finished, MAP declined in both groups but intravenous group showed marked drop and maintained lower value than control group until the end of experiment.
In
the
2nd experiment, the flow rate was 3.8ml/min hy gravity and 4.8ml/min by 150mmHg pressure and showed no statistical difference.
In conclusion, the intraosseous infusion showed superior effect in restoring and maintaining arterial pressure than conventional intraveous infusion in the initial fluid resuscitation of rabbit shock model.
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